What Happens When Agency Administrators Don't Support The Agency's Statutory Mission?

I suspect that lots of people have said it, but President Obama is often credited with saying that elections have consequences. One of those consequences is that the President, generally speaking, gets to select who works for him.

I've always taken the position that, no matter how much I disagree with the President, the Senate should confirm his executive branch nominees (nominations to the Judicial Branch are different, since judges don't work for the President), absent some kind of malfeasance.

The current administration has caused me to modify that view; I've been forced to add a qualifier – the Senate should confirm the President's executive branch nominations, absent some malfeasance – but only if the nominee actually supports the mission of the agency or department to which they have been nominated.