Polymorphs At The EPO - Where Are We Now?

Polymorphs are different crystalline forms of the same chemical compound. Elemental carbon exhibits polymorphism. Both graphite and diamond are pure carbon but have different crystal structures resulting in very different properties (and price tags).

Polymorphism of drug molecules is an important consideration in the pharmaceutical space as different polymorphs can lead to improved properties such as improved solubility, dryability and filterability. Moreover, many drugs will only receive regulatory approval for a single polymorph. Consequently, obtaining a patent to a specific polymorph of a pharmaceutical product can provide a critical layer of protection for drug candidates.